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apc

Member since Jun 2011 • Last active Jan 2021

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    just tried to find a pic of the Braun and realised it 7 years ago! Still love it though.

  • in Miscellaneous and Meaningless
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    Just ordered an SRPE63K1. The only other watch I own is a braun aw20, so first automatic. Wanted a small everyday watch and also something fairly affordable (managed to get for £160)

    Hoping the dial is a fairly subtle sunburst, in some pics it looks a bit over the top, shall see.

  • in COVID-19
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    Yes - I am hopeful that they will exceed target

    One of my Nan's just got hers this morning, a constant stream of oldies coming through. The people organising and giving the vaccine are doing an incredible job.

  • in COVID-19
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    315k doses today
    360k/day avg now required to hit 14M target by 14th feb

  • in COVID-19
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    To be fair they vaccinated 220,000 people yesterday

    To hit target they need to be vaccinating 355,000 people per day, that will increase as each day passes where they are below that but the vaccinations do seem to be going well.

    the UK is undeniably way ahead of other countries in the EU

    Without the vaccine we should have locked down much sooner which would have had a far greater impact than even the fastest vaccine rollout, in my opinion.

  • in COVID-19
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    https://www.telegraph.co.uk/business/202­1/01/13/pills-could-replace-covid-jabs-b­ritish-biotech-breakthrough/

    Putting Covid vaccines into pills could soon move from dream to reality after a Sussex-based biotech signed an agreement with a US pharmaceutical company to test the technology in clinical trials.

    Burgess Hill-based IosBio has found a way to turn injected vaccines into orally administered tablets. The technology is now being used by ImmunityBio, a Californian company developing a vaccine against Covid after signing a licensing agreement with iosBio.

    Clinical trials in monkeys have shown the oral vaccine made using iosBio technology to be highly effective, while the jab version is already in phase two/three trials.

    The oral vaccine will begin clinical trials on Americans this month and ImmunityBio is applying for regulatory approval to run trials in the UK.

    IosBio’s technology is called OraPro. It engineers vaccines into pills that can withstand temperatures of up to 50C, allowing them to pass through the stomach and be directly absorbed into the mucous membranes.

    “You catch Covid in your mucosal cells,” said Wayne Channing, chief executive of iosBio. “But with jabs you get injected into the arm which goes into the muscles and blood cells. Our tablets go straight into mucosal cells to illicit mucosal immunity so we hit the virus where it is.

    “When you catch this virus you breath it in or swallow it and 80pc of your immune system cells are mucosal so we are addressing that directly. I think this will be a new paradigm in vaccination.”

    Under the terms of the licensing agreement, ImmunityBio has exclusive rights to OraPro. In return, IosBio will get royalties on global sales of the approved vaccine.

    “The results from the non-human primate trial were outstanding for oral and I think oral is the right strategy,” Mr Channing added.

    “Patrick Soon-Shiong, the chief executive of ImmunityBio, called me and said he had woken up at 3am and thought, this should be an oral vaccine.”

  • in COVID-19
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    Some good news today:

    1. 2.4 million vaccinated so far (over 1m done in the last week)
    2. Mass vaccination centres opened today
  • in COVID-19
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    know someone from work who went back to IoW over Christmas.. Another colleague had a test came back negative, flew, then did another test once in home country. It came back positive and they infected both their parents who are currently recovering. Happy Christmas!

  • in Miscellaneous and Meaningless
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    What is best plan of action here to stop a gale blowing in

  • in COVID-19
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    find it hard to believe based on the rather morbid measurement of current deaths that anywhere near 100k per day were infected in the spring, given better treatment now etc

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