I really enjoyed fallout 4.
Just try to focus on a few things not being a master of everything. Flying things are annoying but focus on vats or sneak. Sneaking will give you a 2x damage bonus.
Also always have a follower - they will 9 times out of 10 soak up the damage for you.
My first and only gameplay (just finished) was mainly around pistols and sniper rifles.
The playthrough I have just started I am aiming to be melee only so far I have a tire iron and a lot of balls charging into a big group. The first big hurdle will be trying to fight off a deathclaw. On second thoughts I might have to avoid them for a while.