I've done this ride a few times (Rapha London>Manchester route in reverse) and it's great - are you planning to do it all in one day? As it's tough that way round, with about 70km of Peaks at the end.
If you're breaking it up over 2 days, The Boot in Repton is my favoured stop - leaves you a lumpy but short 2nd day into Manchester. It makes it a much nicer trip than trying to do it in a 1-er.
You can cheat in the Peaks and do a bit up the A515 into Buxton which is flatter and faster (but not as nice)