Yes, I usually do.
Last year I had tubeless front and and tubed rear (spare wheel, CBA to fit new tubeless tyre). Then two weekends in succession I had a puncture in the rear (tubed) wheel. Half the people who passed me when I was fixing shouted out 'I thought you used tubeless'
I set it up originally for PBP in 2015. It's generally been good with one failure (on TCR). As comment above, normally you can do the work in the warm at home rather than on the road. On balance it's better but not perfect.
Main reason I switched originally is that it allowed me to run much nicer tyres in the winter than I would dare with tubes. With tubes I used to use heavy, puncture resistant tyres but have mainly used Schwalbe Ones with tubeless and they are lovely to ride on.