Chat about Novel Coronavirus - 2019-nCoV - COVID-19

For me, I'm just wondering how likely it is that CBBC - a channel normally devoted to such intellectual heavyweights as Mr Tumble and the Octonauts - is going to be taking a deep dive into Britain's colonial past.

Hopefully a move in the national curriculum and CBBC would prioritise children’s mental health. And hopefully the channels don’t alienate parents; I suspect distrust in mass media has contributed to covid impact in the UK, and more echo chambers are the last thing we need.

Johnson needs to be sending Trump a Bargain Bucket for taking the media heat off him today.

For a Major Lockdown, traffic is surprisingly busy to the point of congestion.

I’m guessing a lots of workplace are “COVID-SAFE”, and a lots of people still going to work during the lockdown.

We were issues with letter to “prove” we are going to work, don’t think we need it on account of the traffics.

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I was issued a letter the first time but didn't need to go to work. This time no letter but yesterday I went to a datacentre. Maybe I should ask for an updated letter.

In the "why am I stuck in traffic" shocker, I thought the same while taking mini_com to the childminder (before anyone starts, they're 4 miles away, I do not have a baby friendly bike and fucked if we're using public transport atm). Traffic almost feels heavier, like the same number of people are moving about, just more so in cars.

The thing is, I think, coronaviruses (or this one) from here
https://www.nature.com/articles/d41586-020-02544-6#:~:text=A%20typical%20SARS%2DCoV%2D2,the%20University%20of%20Basel%2C%20Switzerland.

is that they mutate quite slowly.

From that article, the first big change would have been the one that allowed it into the human system. Then it's in a place primed to attack it. Unless you have a fucked immune system.
Then it replicates away making changes at 1 -2 bases per month (from that same article). However, I'd guess if it is still capable of "fucking you up son" then replicating away in an immunocomp person means that it will fuck up the host. So I'm not sure, but then it's been a really long time since I thought or read anything proper science, that having an immunocomp host is a good thing for low virulence selection (which is what a virus wants really - I think).
Having no immune response will have no selection pressure on the virus from the hose and will let mutations (1-2 a month per genome) accumulate, but with big selection pressure from the virus and its ability to fuck up the host.

Having a functioning immunoresponse will select for those mutations that make it unrecognisable to the immune system. But these mutations may or may not confer an advantage to the virus.

Does that make sense?

Did you mean this article?
https://www.cogconsortium.uk/news_item/persistent-sars-cov-2-infection-and-viral-evolution-tracked-in-an-immunocompromised-patient/

https://www.cogconsortium.uk/news_item/update-on-new-sars-cov-2-variant-and-how-cog-uk-tracks-emerging-mutations/

"Clap for the NHS" is back and has been rebranded "Clap for heroes".

more worthless, performative bullshit from the thoughts and prayers brigade. fucking fuck this.

https://www.lfgss.com/comments/15735869/

Any suggestions for how to support them?

don't vote for the fucking tory party.

How long have you got? Clapping is a very empty gesture at this stage.

Echoes of the Help for Heroes/Buy treats for war criminals bullshit.

Instead of clapping they can start paying the NHS 350mil a week as they so proudly advertised.

4,100 deaths in the USA yesterday.

The SAGE virology professor on QT last night was quite open about the dosing schedule changes.

In a perfect world they'd stick to the ideal dosing schedule as recommended by the manufacturer, but the problem is that to do that the vaccine rollout would take longer to get to everyone for a first dose and so there would be more preventable deaths amongst the proportion of the initial high risk cohorts that have to wait longer to get theirs.

The fundamental problem is that the supply of the vaccine is rate limited by the manufacturers, they can't make it quick enough.

A bit simplified but...

If you've got 14 million high risk people to vaccinate in the initial cohorts identified then that's 28 million doses you need. That's 14 weeks of supply.

a) So you either give everyone one dose within the first 7 weeks, and so they start to acquire some level of immunity quicker than if you...

b) Follow the ideal plan (assuming 14 days apart to make it easier) which means a wait of up to 12 weeks for their first dose for some people.

(Of course, the UK Government will undoubtably fuck up the administration of the vaccine so that suppliers won't actually be the real bottleneck.)

matt hancock makes a visit to a gp surgery to see how well the vaccination programme is going in front of a waiting media

lots of photos of no injections going on because the vaccines haven't arrived yet

the pm's media person was right when she said he's working " to his utmost ability "

shambles

https://vaccinationvolunteers.sja.org.uk/

Volunteers wont be paid?

6 weeks since our last ONS test. They seem to have gone silent on us.

I finally got my results an the other remaining 2, 7 days after testing.
No surprises all positive.

How are you guys all feeling?

I’ve had it the worst it would seem, probably got it just after the festive 500, so that may have contributed.
All fairly mild. My wife has been bit fatigue today but otherwise very little to note. Little ones hardly noticed.

Clearly Man-Covid...
Glad you're all pretty much ok.

People are anecdotally dropping like flies here in Hampshire.
Outbreaks in the local large Sainsburys, 24h Asda, lots of staff off sick.
Our cleaner and all her and her extended family have it, (haven't seen her since before Xmas though fortunately), wife's office suspected cases have tested positive.
It really feels as if the net is tightening...