Since most newer bikes have vertical dropouts, people have gotten used to wimpy aluminum skewers, and often don't adjust them as tightly as they might.
If you use a good quality (Shimano is the best) skewer , tightened securely, it will hold just fine in any type of dropout or fork end .
A quick release is a considerable timesaver in switching a flip-flop wheel around, and having a QR means that you don't need to carry a big wrench to be able to replace a damaged inner tube.
sheldon brown to the rescue