The only concern I would have is that there's nothing keeping the bolts or hanger captive once the wheel is installed. Hanger bolts have a habit of creeping out after repeated stress from a shifting derailleur. Admittedly, that's normally with the tiny M3 jobbies that most brands use, so maybe with a couple of beefy M5s it won't be an issue.
Have you considered Nyloc/Tuflok/Torq-Patch bolts instead?
I guess you (hopefully) won't have to change the hanger that often - but they can be used again and you don't have to wait for the loctite to cure
The only concern I would have is that there's nothing keeping the bolts or hanger captive once the wheel is installed. Hanger bolts have a habit of creeping out after repeated stress from a shifting derailleur. Admittedly, that's normally with the tiny M3 jobbies that most brands use, so maybe with a couple of beefy M5s it won't be an issue.