Re low gearing chat, the GRX rear mech will work 11-42 x 50/34
If you need that low a gear surely you don't need a 50 X 11? Sure, range is good but the jumps in that cassette are huge.
Worst of both worlds. Massive, heavy cassette with big jumps and annoying front shifting. Extra anti points for being in a full road bike
I ran 11-42 with 46/34 rings during Transiberica using a stock Ultegra DI2 R8000 RD setup.
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