Yes, Europe in the 1600s. Crusades. Black Plague.
You may be a couple of centuries out on that. Crusades were put on pause from the 1400s through to the 2000s, and plague was long gone by the C17th.
London had the Plague 1665/66, it ended in the same year as the fire but it's not the fire that ended it. QI fact.
Yeah, lots of outbreaks of plague since the C15th (including quite recently in Africa iirc), but not really as a major Europe-wide population decimator.
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You may be a couple of centuries out on that. Crusades were put on pause from the 1400s through to the 2000s, and plague was long gone by the C17th.